Choix du traitement de première intention pour le cancer des voies biliaires avancé non résécable
Résumé
Les cancers des voies biliaires (CVB) constituent un ensemble de tumeurs malignes hétérogènes qui se développent à partir des voies biliaires (cholangiocarcinome intrahépatique [iCCA], cholangiocarcinome extrahépatique [eCCA] et cancer de la vésicule biliaire). Collectivement, ces néoplasies ont un pronostic sombre, attribué au stade avancé auquel elles sont diagnostiquées. Le CVB de stade avancé avait auparavant la réputation d’être moins sensible à la chimiothérapie. Cette théorie qui a été remise en cause au cours de la dernière décennie, probablement grâce à l’amélioration des techniques de drainage biliaire qui ont permis d’améliorer la fonction hépatique. Peu de progrès ont été réalisés dans le traitement des CVB avancés et non résécables au cours des quelques dernières années.
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