Traitement du cancer colorectal métastatique associé à une dSRM en 2025
Résumé
Le cancer colorectal métastatique (CCRm) associé à une déficience du système de réparation des mésappariements (dSRM) ou à une instabilité microsatellitaire élevée (IMS-E), qui représente environ 4 à 5 % des cas de CCRm, constitue un sous-groupe moléculaire distinct ayant des implications thérapeutiques uniques. Ces tumeurs malignes se caractérisent par une charge mutationnelle élevée et une infiltration accrue des cellules immunitaires, ce qui les rend particulièrement sensibles aux inhibiteurs de points de contrôle immunitaires (IPCI). À l’inverse, ce sous-groupe a tendance à être moins sensible à la chimiothérapie traditionnelle.
Références
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