Revue du cancer du poumon non à petites cellules (CPNPC) porteur de mutations de l’EGFR en 2024
Résumé
Il y a vingt ans, notre compréhension du traitement du cancer du poumon non à petites cellules (CPNPC) a été révolutionnée par la démonstration d’une forte relation entre les mutations activatrices du domaine de la tyrosine kinase du récepteur du facteur de croissance épidermique (EGFR) et la réponse aux inhibiteurs de tyrosine kinase (ITK) tels que le géfitinib. Ces expérimentations, parmi beaucoup d’autres, ont ouvert la voie à deux décennies de croissance exponentielle des thérapies dont nous avons été témoins.
Les cancers du poumon porteurs de mutations de l’EGFR représentent jusqu’à 23 % des cas de CPNPC diagnostiqués au Canada, avec des variations significatives en fonction de la géographie et de l’ethnicité, notamment une prévalence plus élevée dans les régions où la population asiatique est plus importante. Par conséquent, les données les plus récentes qui seront présentées dans cet article peuvent potentiellement améliorer les résultats pour un grand nombre de patients.
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